Subependymal giant cell astrocytoma, report of a rare case

Behnaz Darvishi; Negin Farhad; Mazaher Ramezani

doi:10.18502/bccr.v14i1.14385

Behnaz Darvishi Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Negin Farhad Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mazaher Ramezani Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

DOI: https://doi.org/10.18502/bccr.v14i1.14385

Keywords: Subependymal giant cell astrocytoma, Tuberous sclerosis complex

Abstract

Tuberous sclerosis complex (TSC) is a rare genetic disease that is inherited autosomal dominantly and may be associated with subependymal giant cell astrocytoma (SEGA) in 10-20% of cases. Different phenotypes are related to the form of lesions in different parts of the body, including skin, brain, kidneys, lungs, and heart. The age of the patient, the location of the tumor, and associated skin or neurological lesions may guide the pathologist for a definite diagnosis. Here we report a case of SEGA in an adolescent with TSC. Neurological clues including seizure and mental retardation, facial angiofibroma, renal mass, and histopathology examination of the brain tumor culminated in the diagnosis of TSC and SEGA.