Anticancer Effects of Copper (II) Hydrazone Schiff Base Complex: A review

Roghayeh Fekri; Arash Abdolmaleki; Asadollah Asadi; Mehdi Salehi; Aida Karimian; Leila Taghizadehmomen; Rehab K. Raheem; Lia Karimian

doi:10.18502/bccr.v13i2.10029

Roghayeh Fekri Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Arash Abdolmaleki Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran
Asadollah Asadi Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Mehdi Salehi Department of Chemistry, College of Science, Semnan University, Semnan, Iran
Aida Karimian Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Leila Taghizadehmomen Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Rehab K. Raheem Department of Chemistry, College of Education for Pure Sciences, Ibn -Al-Haitham, University of Baghdad, Baghdad, Iraq
Lia Karimian Department of Chemistry, College of Science, University of Guilan, University Campus 2, Guilan, Iran

DOI: https://doi.org/10.18502/bccr.v13i2.10029

Keywords: Anticancer, Copper (II) complexes, Hydrazone, Schiff base ligands

Abstract

Cancer treatment has traditionally consisted of established treatments such as radiation, surgical excision, and chemotherapy, which can be used alone or in combination. Many therapeutic factors have been extracted from minerals, plants, and animals. The majority of them have been synthesized in the lab, making them a valuable source of innovation pharmacologically. A growing interest in metal complexes in cancer treatment is due to their cytotoxic effects in vitro. The electronic nature of metals, modifications in ligands, and conformational changes in functional groups give rise to the discovery of drugs with different cytotoxic and pharmacokinetic properties. In recent decades, the number of people receiving chemotherapy has increased considerably. Medicinal inorganic chemistry can take advantage of the unique properties of metal ions to generate new drugs. This has prompted chemists to use various approaches to create novel metal-based anticancer drugs with various mechanisms of action, which are significant in the pharmaceutical industry due to their potent anticancer properties. Schiff base ligands and transition metals are the most researched coordination chemicals. Their applications as anticancer medicines are becoming more significant. This review analyzes various publications on copper complexes based on Schiff base hydrazone ligand in cancer treatment.