Application of Novel Molecular Biology in Cancer Therapy

Arash Abdolmaleki; Aida Karimian; Asadollah  Asadi; Hussein A. Ghanimi; Muhammad Akram

doi:10.18502/bccr.v13i2.10024

Arash Abdolmaleki Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran
Aida Karimian Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Asadollah Asadi Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Hussein A. Ghanimi College of Nursing, University of Al-Ameed, Karbala, PO Box 198, Iraq
Muhammad Akram Department of Eastern Medicine, Government College University Faisalabad-Pakistan

DOI: https://doi.org/10.18502/bccr.v13i2.10024

Keywords: Brain Tumor, Cancer, Molecular Biology, Oncogenes

Abstract

Cancer is a genetic illness that develops for various reasons, including the activation of oncogenes, the failure of tumor suppressor genes, or mutagenesis induced by environmental stimuli. This article was produced using PubMed, Nature, Science Direct, Springer, and Elsevier data. Oncogenes are altered forms of normal proto-oncogenic genes that are important for cell proliferation, development, and regulation. The transformation of a gene to an oncogene is caused by chromosomal translocation or gene mutation due to addition, deletion, duplication, or viral infection. These oncogenes are targeted by medications or the RNAi system to limit malignant cell development. Various molecular biology methods for cancer detection and treatment have been developed, including targeting cancer stem cell pathways for cancer therapy, retroviral therapy, oncogene silencing, and alterations in tumor suppressor genes. Among all the techniques used, RNAi, zinc finger nucleases, and CRISPR have a greater chance of reaching a cancer-free planet.