Efficacy of Omega-3, -6, and -9 Fatty Acids, Alone or in Combination With Low Dose Aspirin, in Improvement of Uterine Blood Flow in Women With History of Recurrent Miscarriage: A Prospective, Randomized, Clinical Trial

Shahram Ala; Sepideh Payvandi; Maryam Barzin; Mahdieh Tavajoh; Hamidreza Samaei

doi:10.18502/pbr.v8i1.9387

Shahram Ala Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Sepideh Payvandi Department of Obstetrics and Gynecology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Maryam Barzin Department of Radiology, Imam Khomeini Hospital, Mazandaran University of Medical sciences, Sari, Iran.
Mahdieh Tavajoh Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Hamidreza Samaei Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

DOI: https://doi.org/10.18502/pbr.v8i1.9387

Keywords: Recurrent miscarriage, Omega-3, -6, and -9, Aspirin, Uterine blood flow

Abstract

Background: Much evidence suggests that increased uterine blood flow resistance (reduced uterine perfusion) raises the risk of Recurrent Miscarriage (RM).

Objectives: This study aimed at evaluating the efficacy of omega-3, -6, and -9 fatty acids, alone or in combination with aspirin, in reducing uterine blood flow resistance in women with a history of RM.

Methods: A total of 45 women with a history of two or more miscarriages and increased uterine artery blood flow resistance were included in this randomized clinical trial. They were randomly assigned to aspirin (80 mg/d) (group A, n=15), omega-3, -6, and -9 fatty acids (4800 mg/d) (group O, n=15), or combination therapy (group AO, n=15). The patients were visited after two months, and the uterine artery blood flow resistance was measured by Doppler sonography.

Results: The Mean±SD age of participants was 32±3.5 years in group A, 32±3 years in group O, and 32.4±3 years in group AO. There was no significant difference between three groups in age (P=0.7), duration of marriage (P=0.55), duration of infertility (P=0.43) and number of previous miscarriages (P= 0.51). In all three groups, after two months of treatment, the average uterine artery blood flow resistance reduced considerably compared with the beginning of the trial (P=0.0001); however, there was no significant difference between the three groups (P=0.56).

Conclusion: According to the study results, omega-3, -6, and -9 fatty acids can reduce uterine artery blood flow resistance and improve the uterine blood flow in women with RM, with equal efficacy to aspirin. Also, combination therapy offers no advantages over monotherapy.