A Case of Erythema Multiforme Caused by Sildenafil Plus Tramadol

Amir Hossein Ghanbarzamani; Ebrahim Salehifar; Kaveh Kazemian

doi:10.18502/pbr.v7i1.7358

Amir Hossein Ghanbarzamani Pharmaceutical Research Center, Department of Clinical Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Ebrahim Salehifar Pharmaceutical Research Center, Department of Clinical Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Kaveh Kazemian Department of Clinical Pharmacy, Sina Hospital, Tehran University of Medicine, Tehran, Iran.

DOI: https://doi.org/10.18502/pbr.v7i1.7358

Keywords: Erythema multiforme, Sildenafil, Tramadol

Abstract

In this report, we present a 29-year-old man who experienced EM five days after using sildenafil and tramadol. Based on clinical examination and history, the diagnosis of EM was made confirmed via skin biopsy, which found intra-epidermal bulla filled by fibrinous exudate, some mononuclear cells, and a few eosinophils. The spongiotic epidermis showed lichenoid interface dermatitis, eosinophilic spongiosis, and necrolysis, consistent with EM diagnosis. Fluocinolone, 0.025% ointment, was prescribed for the patient, and the lesions healed after two weeks of treatment.