Evaluation of L-Carnitine Potential in Improvement of Male Fertility

Leila  Kooshesh; Zohre  Nateghian; Elham  Aliabadi

doi:10.18502/jri.v24i2.12491

Leila Kooshesh Department of Genetics, Fars Academic Center for Education, Culture and Research, ACECR, Shiraz, Iran
Zohre Nateghian Islamic Azad University of Isfahan (Khorasgan) Branch, Isfahan, Iran
Elham Aliabadi Department of Anatomy, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/jri.v24i2.12491

Keywords: Busulfan, L-carnitine, Male fertility, Radiation, Sperm cryopreservation.

Abstract

L-carnitine, through its antioxidant potential, plays a significant role in reducing ROS production in male genital tract; therefore, fundamental improvements in spermatogenesis process and sperm structural and functional parameters in seminal plasma can be observed by treatment with L-carnitine. A literature search was performed using PubMed (including Medline) from the database earliest inception to 2021. Eligibility criteria included studies on protective effects of L-carnitine against damages to the male reproductive system. Based on the findings of the current study, L-carnitine has an effective potential to protect testis and improve conventional and functional sperm parameters against ROS-induced damages by sperm cryopreservation, busulfan treatment, and radiation