Plant-Derived Metabolites as Potent Inhibitor and Treatment for COVID-19

  • Roghaieh Holghoomi PhD graduate in Plant Physiology, Urmia University, Urmia, Iran.
  • Arash Abdolmaleki Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
  • Asadollah Asadi Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
  • Mahan Kajkolah Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
  • Krishnamoorthy Gurushankar Laboratory of Computational Modeling of Drugs, Higher Medical and Biological School, South Ural State University, Chelyabinsk-454 080, Russia.
  • Mahmoud Bidarlord Department of Forests and Rangelands Research, Gilan Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Rasht, Iran.
Keywords: Coronavirus; Biological Products; Phytotherapy


Pandemic disease, COVID-19, caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals, generated global panic. Medicinal phytochemicals have a lengthy history of being used to treat a wide range of pathogens and diseases. The utilization of natural plant products will be the subject of this review, based on the results of previous researches in preventing the infection of COVID-19. In this review, all data sources including Google Scholar, Scopus, PubMed, and Science Direct were searched for publications with no particular time restriction to get a holistic and comprehensive view of the research. It was seen that plants natural products like Polyphenols, Alkaloids, Flavonoids, Coumarins and essential oils were able to inhibit main targets in the virus life cycle such as main protease (Mpro), SARS CoV 2 helicase Nsp13 and Angiotensin Converting Enzyme (ACE2). It has been established that natural plant derivatives can be utilized for treating and prevent SARS-CoV-2 and other coronaviruses by inhibiting several prominent viral portions. However, it is imperative to emphasize on standardization and control the quality of medicinal plants-based products in future studies and there should be further properly investigations of these products in order to clinical usage against COVID-19 infection.