Supplemental Preparations in Taxane-Induced Neuropathy Management

AmirHosein Sanei; Farshad Abedi; Mohammad Moeini Nodeh; Amir Hooshang Mohammadpour; Abolghasem Allahyari; Fariba Zemorshidi; Omid Arasteh

doi:10.18502/jpc.v11i1.12639

AmirHosein Sanei School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Farshad Abedi Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Moeini Nodeh Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences Mashhad, Iran.
Amir Hooshang Mohammadpour Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abolghasem Allahyari Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences Mashhad, Iran.
Fariba Zemorshidi Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Omid Arasteh Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: https://doi.org/10.18502/jpc.v11i1.12639

Keywords: Chemotherapy;Taxane;Peripheral Neuropathy; Supplements

Abstract

Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect of chemotherapy without any specific treatment. The aim of this paper is to evaluate the effects of natural products and supplements on TIPN. PubMed, Google Scholar and Web of Science databases were searched through August 2022 regarding TIPN and effects of natural products and supplement therapy. Data consists of preclinical studies, randomized controlled trials and case reports. After screening of 230 papers, we found 13 relevant animal and human studies regarding possible benefits of vitamin E, glutamine, omega-3, acetyl-L-carnitine and group of B vitamins on TIPN. Results demonstrated that vitamin E can be helpful on prevention and duration of TIPN. Glutamine and B vitamins showed hopeful results on reducing pain sensation. Omega-3 also shows promising results on incidence of TIPN. However, acetyl-L-carnitine might develop and worsen neuropathy. Although some supplements revealed promising effects on prevention and treatment of TIPN, researches are still limited and we need further long-term large sample size trials to confirm clinical efficacy of these supplements.