Celiac Disease Seropositivity in Dilated Cardiomyopathy Patients and Correlation with Ejection Fraction

Ali Rashidinia; Ali Bozorgi; Alireza Abdollahi; Alvand Naserghandi; Bahar Ataeinia; Seyed Farshad Allameh

doi:10.18502/jimc.v5i1.9582

Ali Rashidinia Department of Gastroenterology, Tehran University of Medical Sciences, Tehran, Iran
Ali Bozorgi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Alireza Abdollahi Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
Alvand Naserghandi Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bahar Ataeinia Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA, USA
Seyed Farshad Allameh Department of Gastroenterology, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jimc.v5i1.9582

Keywords: Celiac disease, Dilated cardiomyopathy, Ejection fraction, Serology

Abstract

Background: Recent evidence suggests a connection between celiac disease and dilated cardiomyopathy. Herein, we serologically screened for celiac in dilated cardiomyopathy patients and investigated its correlation with ejection fraction.

Methods: We selected 123 cardiomyopathy patients. Patients were screened for celiac, using anti-tissue transglutaminase (ATA), anti-gliadin (AGA), and anti-endomysial (EMA) immunoglobulin type A (IgA) antibodies. Total IgA levels were also measured.

Results: Of 123 patients, 3 were EMA positive (2.4%), 4 were AGA positive (3.3%) and 5 were ATA positive (4.1%). EMA positive patients had significantly lower EF values compared to EMA negative patients (35±5 vs. 46.52±9.21, p-value: 0.034). Similar results were observed for AGA (32.5±14.34 vs. 46.7±8.8, p-value: 0.002), but not for either ATA positivity (40±10 vs. 46.5±9.21, p-value: 0.126) or IgA deficiency (50±5 vs. 46.14±9.37, p-value: 0.480). No significant difference was observed in the age and gender of seropositive patients compared to seronegative.

Conclusion: We observed a higher prevalence of celiac seropositivity among dilated cardiomyopathy patients compared to the general population. EMA and AGA positive patients had significantly lower ejection fractions compared to their negative counterparts.