Association between Serum Uric Acid and Mortality Rate among Admitted Patients in Intensive Care Unit

Seyedeh Sahereh  Mortazavi Khatibani; Haniyeh Sadat  Fayazi; Maryam  Vahdani; Ehsan Kazemnezhad  Leyli; Maryam  Yaseri

doi:10.18502/jimc.v9i3.21832

Seyedeh Sahereh Mortazavi Khatibani Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Haniyeh Sadat Fayazi Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Maryam Vahdani Clinical Research Development Unit, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Ehsan Kazemnezhad Leyli Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran
Maryam Yaseri Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

DOI: https://doi.org/10.18502/jimc.v9i3.21832

Keywords: Acute physiology and chronic health evaluation, Intensive care unit, Mortality, Serum uric acid

Abstract

Background: Patients admitted to the Intensive Care Unit (ICU) generally exhibit high mortality rates, of which identifying associated factors can lead to better clinical management. The current study investigated the association between serum uric acid levels and mortality rates in patients admitted to ICU.

Methods: In this cross-sectional study, demographical, clinical, and laboratory data of 126 patients admitted into the ICU of Razi Hospital, Rasht, Iran, were recorded. Also, the serum levels of creatinine and uric acid were evaluated. The severity score and mortality estimation was assessed using the Acute-Physiology-and-Chronic-Health-Evaluation-II (APACHE II) score. Data was analyzed using SPSS software, version 21, and the significant level was set at 0.05.

Results: About 57.9% of the patients were male and 42.1% were female. The mean age of the patients was 56.46±17.02 years. The mean level of uric acid was 4.13±1.94 mg/d. Among different cause of ICU admission, surgery was the leading cause (38.89%), of which 69.05% were discharged, and the average ICU stay was 10.87±8.75 days. Patients requiring ventilators or vasopressors had significantly higher mortality rates (p<0.001). Higher APACHE II scores, longer ICU stays, and elevated uric acid levels were strongly associated with increased prevalence of mortality (p<0.05). Logistic regression analysis confirmed that the need for ventilators, vasopressors, and elevated uric acid levels significantly raised the death outcome among ICU patients with hyperuricemia (p<0.05).

Conclusion: The findings demonstrated that elevated serum uric acid levels are significantly associated with increased mortality rates among patients admitted to the ICU, which suggests that monitoring and managing hyperuricemia may help improve patient outcomes in critical care settings.