The Effect of Vitamin C on Ischemia-Reperfusion Injury: A  Systematic Review

Behnam Masmouei; Ali Zarei; Shamim Kouhi Habibi Dehkordi; Mahmood  Raisi; Fatemeh Rasekh; Mohammad Rafi Bazrafshan; Ali Mohammad Parviniannasab; Reza Firooz  Mohajan Abadi; Saeed Hamidizadeh

doi:10.18502/jimc.v7i2.15033

Behnam Masmouei Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
Ali Zarei Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Shamim Kouhi Habibi Dehkordi Student Research Committee, Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
Mahmood Raisi Student Research Committee, Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Rasekh Department of Biology, Payam Noor University of Tehran, Tehran, Iran
Mohammad Rafi Bazrafshan Department of Nursing, School of Nursing, Larestan University of Medical Sciences, Larestan, Iran
Ali Mohammad Parviniannasab Department of Nursing, School of Nursing, Larestan University of Medical Sciences, Larestan, Iran
Reza Firooz Mohajan Abadi Student Research Committee, Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
Saeed Hamidizadeh Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/jimc.v7i2.15033

Keywords: Ascorbic acid, Ischemia, Reperfusion injury

Abstract

Ischemia is one of the most common injuries that is usually caused by reduced blood flow to the tissues. Following this incident, the tissue becomes deficient in oxygen and nutrients, and energy production in the affected cells stops, eventually leading to cell damage, but there is also evidence that restoring blood flow to ischemic tissues can lead to extra tissue damage known as Ischemia Reperfusion Injury (IRI). In this study, we reviewed the relationship between vitamin C intake and ischemia/reperfusion injury to investigate the relationship between vitamin C intake and ischemia/reperfusion injury. The keywords “Vitamin C” or “Ascorbic Acid” and “Ischemic” or “Ischemia” and “Reperfusion” were used in this search. The results show that vitamin C has a positive effect on ischemia treatment in the renal tissue, brain, liver, intestine, lung, ovary, pancreas, and skin.