Estimating the Adverse Reaction Among Iranian Blood Donors: The First National Report

Moslem Taheri Soodejani; Seyyed Mohammad Tabatabaei; Aliakbar Haghdoost; Masoud Amiri; Mohammad Reza Baneshi; Abbas  Sedaghat; Farzaneh Zolala

doi:10.18502/jimc.v7i1.14200

Moslem Taheri Soodejani Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyyed Mohammad Tabatabaei Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Aliakbar Haghdoost HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Masoud Amiri Dep. of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Mohammad Reza Baneshi Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Abbas Sedaghat Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Farzaneh Zolala HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

DOI: https://doi.org/10.18502/jimc.v7i1.14200

Keywords: Blood safety, Hemovigillance, Adverse effect

Abstract

Background: The aim of this study was to estimate the incidence of reactions caused by blood donations in Iran as well as exploring three potential scenarios of the worst, moderate, and the best situations for adverse reactions among Iranian blood donations by specifying the under-reporting rate.

Methods: There are two different designs; first, the ecological study was coducted to estimate the blood donation adverse effects by using the data registered in the donor vigilance part of Iranian Blood Transfusion Organization (IBTO). Second, the cross-sectional study was conducted to estimate under-reporting in the data. For the cross-sectional study, 2408 donors were selected randomly in three cities.

Results: In general, based on the estimations of this study, adverse reactions to blood donation in Iran is 2%(CI 95%, 1.4-2.6%). Local and systemic reactions estimated are 1.7%(CI 95%, 1.2-2.2) and 0.3%(0.1-0.5), respectively. Based on the national report, in general, adverse reactions to blood donation in Iran is 0.5(CI 95% 0.4-0.6). Local and systemic reactions estimated are 0.38%(CI 95% 0.28-0.48) and 0.03%(0.0.02-0.04), respectively.

Conclusion: Adverse reactions may vary from region to region in Iran, but in total, there is a lot of under-reporting in the incidence of adverse reactions to blood donation in Iran, most of which are related to local reactions.