The Comparison of Efficacy and Complication of Desloratadine with Fexofenadine in Patients with Allergic Rhinitis: A Randomized, Double-Blind Clinical Trial

Niloufar Sadat Sadredini; Atefeh Fakharian; Maryam Sadat Mirenayat; Sara Amini; Negar Khoshbari; Reyhaneh Zahiri; Hamid Reza Jamaati

doi:10.18502/jimc.v6i2.12237

Niloufar Sadat Sadredini Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Atefeh Fakharian Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Sadat Mirenayat Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sara Amini Howard university college of pharmacy, Washington, DC, USA
Negar Khoshbari Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reyhaneh Zahiri Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hamid Reza Jamaati Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jimc.v6i2.12237

Keywords: Allergic rhinitis, Desloratadine, Fexofenadine

Abstract

Background: Allergic rhinitis is a very common disease which its clinical symptoms can reduce the patient’s quality of life. This study aimed to compare the effects and side effects of desloratadine with fexofenadine on allergic rhinitis.

Methods: The present study is a clinical trial on 68 patients with allergic rhinitis who were randomly divided into two groups named A and B. In the A group, patients used 120 mg of fexofenadine for 4 weeks and in the B group, patients received 5 mg of desloratadine for 4 weeks. After two weeks of rest, patients in the A group received desloratadine, and patients in the B group received fexofenadine for 4 weeks. Then, the clinical conditions and efficiency of the drugs in both groups were compared.

Results: The severity of symptoms significantly decreased in the A and B groups before and after the treatment (p<0.001 and p=0.007, respectively). The severity of symptoms after taking the first and second drugs in the A group was lower than in the B group. In the A group, the changes in symptom severity after taking the first and second drugs were significantly greater than in the B group. Other symptoms were not significantly different between the two treatment groups (p>0.05 in all cases).

Conclusion: In patients with allergic rhinitis, the use of fexofenadine compared to desloratadine can more effectively reduce the severity of the symptoms of the disease and can be prescribed as a suitable treatment option for these patients.