Evaluation of Serum Vitamin D Level and its Effect on the Severity of Disease in Patients with Inflammatory Bowel Disease

Reza Taslimi; Nasser  Ebrahimi Daryani; Najmeh Abbasi; Ali Niksirat; Farnaz Farsi; Alvand Naserghandi; Bahar Ataeinia; Seyed Farshad Allameh

doi:10.18502/jimc.v6i1.11847

Reza Taslimi Department of Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Nasser Ebrahimi Daryani Department of Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Najmeh Abbasi Department of Emergency, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Ali Niksirat Department of Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Farnaz Farsi Colorectal research center, Iran University of Medical Sciences, Tehran, Iran
Alvand Naserghandi Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bahar Ataeinia Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA, USA
Seyed Farshad Allameh Department of Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jimc.v6i1.11847

Keywords: Crohn’s disease, Inflammatory bowel disease, Ulcerative colitis, Vitamin D deficiency

Abstract

Background: Evolving evidence indicates the role of vitamin D deficiency in the progression of IBD and its impact on the severity of the disease, but it remains unclear whether vitamin D deficiency causes IBD or vice versa.

Methods: This cross-sectional study was conducted to determine the serum levels of vitamin D and its effects on the severity of disease in patients with inflammatory bowel disease in the Imam Khomeini Hospital complex. A questionnaire containing demographic information, records on the use of supplements and medications, disease complications, and criteria for determining the severity of the disease based on the Mayo score and Crohn’s Disease Activity Index (CDAI) and 25 hydroxy vitamin D levels was completed and evaluated.

Results: Of the 101 participants, 21 were with Crohn’s disease and 80 had ulcerative colitis. The mean age of Crohn’s patients was 33.80±9.5 years and ulcerative colitis was 38.43±10.2 years. Among patients with ulcerative colitis, 37 (46.8%) had a mayo score less than 3 and 42 (53.2%) were 3 and more. Mean vitamin D in the mayo score less than 3 was 32.14 and the mayo score 3 and more was 23.99. Of the Crohn’s patients, 12 (57.1%) were in the recovery phase and 9 (52.9%) were in a non-recovery phase. The mean of vitamin D in the recovery phase was 29.10 and in the others was 27.04

Conclusion: There is a significant relationship between the level of vitamin D supplementation, the final value of CDAI, and the identification of the patients with the Mayo score.