Removal of Fexofenadine and Montelukast Drugs from Aquatic Environment Using a Rhodotron Accelerator

Omid  Abouee Mehrizi; Seid Kamal  Ghadiri; Fatemeh  Anvari; Parinaz  Mehnati

doi:10.18502/jehsd.v9i2.15845

Omid Abouee Mehrizi Department of Medical Physics, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran.
Seid Kamal Ghadiri Department of Environmental Health Engineering, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Environmental and Occupational Health Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
Fatemeh Anvari Central Iran Radiation Processing Complex, Nuclear Science and Technology Research Institute, Yazd, Iran.
Parinaz Mehnati Radiation Medical Sciences Research Center, Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz Iran.

DOI: https://doi.org/10.18502/jehsd.v9i2.15845

Keywords: Aqueous Solution, Rhodotron Accelerate, Drug, Kinetics.

Abstract

Introduction: Nowadays, the management of drug effluents, as emerging pollutants, has attracted great attention due to human health and ecological adverse effects. During the COVID-19 pandemic, two drugs, Fexofenadine and Montelukast, have been used in large quantities for patients with lung involvement. The aim of this study is to investigate the feasibility of removing Fexofenadine and Montelukast and determine the removal kinetics.

Material and methods: In this study, we used Rhodotron accelerator to determine kinetic coefficients for the removal of drugs. Our research focused on studying the kinetics of E-Beam radiation reactions and the generation of significant amounts of free radicals during these processes. We employed first-order and second-order kinetic models under laboratory conditions, taking into account various influencing factors to establish the rate of removal.

Results: The results showed that the decomposition of Fexofenadine and Montelukast drugs by high-energy E-Beam bending process is a pseudo-first-order reaction with a coefficient of more than 0.9105 and 0.998, respectively. The results showed that the reaction rate constant depended significantly on the initial concentration of Fexofenadine and Montelukast drugs and their molecular structure.

Conclusion: Using a Rhodotron accelerator is important for removing Fexofenadine and Montelukast from the aquatic environment.