Population Attributed Risk (PAR) of Hyperuricemia for Diabetes Mellitus in 20-74-Year-Old Population of Yazd during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort (YHHC), Iran
Abstract
Introduction: Regarding the high impact of Diabetes Mellitus type II (DM II) on human's health, it seems that identifying DM II risk factors is important to prevent its development. Further studies are needed to ensure the positive role of uric acid in the onset of diabetes. This study targeted at investigating the attributed risk of hyperuricemia for the onset of DM II.
Methods: In the present study, 1641 non-diabetic people, selected through multi-stage random cluster sampling, were followed up for 10 years (2006 - 2016). During the study, data on the variables of the study were collected and entered in SPSS 16 which was used to analyze the data. To calculate the attributions of hyperuricemia in the risk of developing diabetes, Levin's formulas and attributed risk related to the prevalence of exposure during these ten years were used.
Results: Findings showed DM II was developed in 54.8% of people with hyperuricemia, whereas 28.2% of people with normal uric acid level developed diabetes. The Population Attributed Risk (PAR) of hyperuricemia and uric acid over than 75th percentile of serum uric acid for DM II incidence were calculated by the weighted attributed risk formula was 3.6 % and 26.6 %, respectively. With the treatment of serum uric acid over than 75th percetile, the incidence of diabetes in population was reduced to 24.2% over a 10-year period.
Conclusion: In this study, there was a significant correlation between high uric acid level and the risk of diabetes. Therefore, necessary measurements should be taken to treat the hyperuricemia patients in order to prevent the incidence of diabetes caused by high blood acid uric.
Keywords: Risk, Diabetes Mellitus, Hyperuricemia, Incidence
