Association between rs1344706 Polymorphism in the ZNF804A Gene and the Risk for Schizophrenia

Aliakbar Esmaeili; Saeedeh Solimani; Farzaneh Karimi; Ebrahim  Miri-Moghaddam

doi:10.18502/ijps.v16i4.7225

Aliakbar Esmaeili Psychiatry and Behavioral Science Research Center, Birjand University of Medical Sciences, Birjand, Iran
Saeedeh Solimani Students Research Committee, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Farzaneh Karimi Department of Biology, School of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Ebrahim Miri-Moghaddam Cardiovascular Disease Research Center, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

DOI: https://doi.org/10.18502/ijps.v16i4.7225

Keywords: Mental Disorder; Polymorphism; Schizophrenia; ZNF804A Protein

Abstract

Objective: Schizophrenia is known as a severe mental disorder worldwide. Genome-wide association studies have revealed that rs1344706, located in ZNF804A, is a risk variant for schizophrenia among various populations. The current study was conducted to find correlation between rs1344706 polymorphism and schizophrenia in East of Iran.

Method: This case-control study assessed 150 schizophrenia cases as well as 150 healthy controls. The single nucleotide polymorphism (SNP) was genotyped using the Tetra-Amplification Refractory Mutation System-Polymerase Chain Reaction (Tetra-ARMS-PCR) method. Analyses based on the Chi-square test and logistic regression were calculated by SPSS.

Results: The TT, GT, and GG genotype frequencies at rs1344706 in schizophrenia cases were 48.0%, 40.0%, and 12.0%, whereas in controls, they were 49.3 %, 36.7 %, and 14.0 %, respectively. The T and G allele frequencies were 68 % and 32 % in cases and 67 % and 33 % in healthy controls. The results of logistic regression indicated that there is no association between rs1344706 alleles (P = 1.000) and genotypes (P = 0.647 for GT and P = 0.726 for GG) with susceptibility to schizophrenia.

Conclusion: Overall, there was no significant relationship between rs1344706 SNP and schizophrenia in Iran's Eastern population. However, further research focusing on more SNPs of ZNF804A and larger samples in other ethnicities is necessary to confirm these results.