Analysis and Identification of Rare and Prevalent Breakpoints in Chromosomal rearrangements in Adult and Pediatric with B-Acute Lymphoblastic Leukemia (B-ALL): A Systematic Review

Roghayeh  Shahshahani; Mehri  Khatami; Mohammad Mehdi  Heidari; Parisa  Naji

doi:10.18502/ijpho.v14i3.15992

Roghayeh Shahshahani Department of Biology, Yazd University, Yazd, Iran
Mehri Khatami Department of Biology, Yazd University, Yazd, Iran
Mohammad Mehdi Heidari Department of Biology, Yazd University, Yazd, Iran
Parisa Naji Department of Biology, Yazd University, Yazd, Iran

DOI: https://doi.org/10.18502/ijpho.v14i3.15992

Keywords: B-Cell Lymphoma, Chromosomal Translocation, Gene Fusions, Oncogene

Abstract

Background: B-cell acute lymphoblastic leukemia (B-ALL) is a complex disorder that includes multiple genetic changes, one of the main causes of which is rare and common chromosomal translocations that lead to abnormal gene fusions. This abnormal fusion produces a new protein that causes the leukemia cells. These types of rearrangements usually occur in lymphoma and result in the movement of genetic material between different chromosomes or within chromosomes. This systematic review aims to evaluate published studies and investigate the role and importance of common and rare chromosomal translocations in the occurrence of B-ALL.

Material and Methods: This systematic review investigated and evaluated the evidence regarding the effect of chromosomal translocations in adults and pediatrics with B-ALL. This review was based on the preferred reporting items for systematic reviews and meta-analysis checklists. A literature search was conducted using international databases (such as PubMed, Web of Science, Scopus, Research Gate, Google Scholar, and Cochrane Systematic Reviews database). Only English-language articles published between January 2010 and January 2023 including MESH terms such as ALL, B-ALL, and chromosomal translocations were selected. Seventy-five related studies had the necessary criteria to be examined in the present study.

Results: A total of 237 articles were retrieved in the online search. The excluded articles included research on other types of leukemia in adults and children, descriptive studies, case studies, studies related to animal models of leukemogenesis, and comparisons of common treatment methods of leukemia grouping cancers. Finally, seventy-five studies were identified as eligible for inclusion in this systematic review.

Conclusion: This review provides a comprehensive assessment of common and rare chromosomal translocations that can lead to the development of cancer cells. Chromosomal translocations play a role as diagnostic markers and important prognostic indicators and help specialists adjust treatment approaches according to their occurrence.