Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis

Rahimeh Sanikhani; Mohammad Moeinirad; Fereshteh Shahcheraghi; Arezou Lari; Sepideh Fereshteh; Amin Sepehr; Afsaneh Salimi; Farzad Badmasti

doi:10.18502/ijm.v13i3.6384

Rahimeh Sanikhani Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Mohammad Moeinirad Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Fereshteh Shahcheraghi Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Arezou Lari Department of Systems Biomedicine, Pasteur Institute of Iran, Tehran, Iran
Sepideh Fereshteh Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Amin Sepehr Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Afsaneh Salimi Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Farzad Badmasti Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran

DOI: https://doi.org/10.18502/ijm.v13i3.6384

Keywords: : Hypervirulent Klebsiella pneumonia; Virulence factors; Molecular typing; Pathotypesi genotypes

Abstract

Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources.