Association of inflammatory scoring tools with spirometry indices in COVID-19 patients: a single center cohort study

Mohsen Farrokhpour; Fahimeh Safarnezhad Tameshkel; Niloufar Sadat Kalaki; Azra Asghari Marzidareh; Aliarash Anoushirvani; Neda Rahimian; Mohammad Hadi Karbalaie Niya

doi:10.18502/ijm.v17i6.20375

Mohsen Farrokhpour Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Fahimeh Safarnezhad Tameshkel Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
Niloufar Sadat Kalaki Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Azra Asghari Marzidareh Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Aliarash Anoushirvani Department of Hematology and Oncology, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Neda Rahimian Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Mohammad Hadi Karbalaie Niya Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/ijm.v17i6.20375

Keywords: COVID-19; Biomarkers; Respiratory function tests; Prognosis; Biological factors; Inflammation mediators

Abstract

Background and Objectives: Patients with COVID-19 have spirometry parameters linked to various biological markers, including CRP, NLR, MPV, RDW, and APACHE II score. The objective of this study was to investigate the association of inflammatory scoring tools with spirometry indices in a three-month follow-up of COVID-19 patients.

Materials and Methods: Spirometry records of 369 COVID-19 cases with complications were analyzed at baseline and three months after discharge. Generalized linear models and logistic regression analysis were performed to compare the variables using SPSS version 25 software.

Results: The baseline NLR was 3.20 (95% CI: 2.96, 3.43); PCT was 0.26 (95% CI: 0.25, 0.27); and MPV was 7.23 (95% CI: 7.10, 7.35). We found that the effects of NLR, CRP, and APACHE II score on the respiratory indices FEV1 and FEV1/ FVC three months after discharge had an inverse relationship. Patients with asthma had significantly lower FEV1 and FEV1/ FVC values, and the level of FVC did not have any significant difference between people with asthma and COPD patients.

Conclusion: CRP, NLR, and APACHE II score are among the main factors that are directly related to respiratory indices and they are considered to be appropriate indicators of prognosis for these conditions in COVID-19 patients.