Lessons from an 11-year retrospective cohort study of Escherichi coli causing UTI in Imam Hospital Ardabil, Iran

Pegah  Shakib; Mohsen  Arzanlou; Pouria  Sobhi; Mehdi  Mojebi; Mohammad  Bahrami; Faraz  Mahdizadeh; Leyla  Asadi; Masoud  Amanzadeh; Alireza  Mohammadnia; Farzad  Khademi; Rashid  Ramazanzadeh

doi:10.18502/ijm.v16i6.17246

Pegah Shakib Razi Herbal Medicines Research Center, Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Mohsen Arzanlou Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Pouria Sobhi Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran
Mehdi Mojebi Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran
Mohammad Bahrami Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran
Faraz Mahdizadeh Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran
Leyla Asadi Imam Hospital Laboratory, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Masoud Amanzadeh Department of Health Information Management, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Alireza Mohammadnia Department of Health Information Management, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Farzad Khademi Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Rashid Ramazanzadeh Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

DOI: https://doi.org/10.18502/ijm.v16i6.17246

Keywords: Urinary tract infection (UTI); Multidrug-resistance (MDR); Escherichia coli (E. coli); Iran; Retrospective stud- ies; Cohort studies

Abstract

Background and Objectives: The global problem of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria is due to limited treatment options. This study aimed to examine the prevalence, etiology, and management implications of Escherichi coli causing UTI at Imam Hospital Ardabil, Iran.

Materials and Methods: 2340 samples of retrospective data on E. coli causing UTIs were collected at Imam Hospital in Ardabil, Iran, spanning from 2012 to 2022. The samples were cultured and isolated, and their antibiotic susceptibility was determined using standard laboratory methods and data were then organized and systematically categorized using Python.

Results: It was found that the lowest level of resistance was related to nitrofurantoin, followed by imipenem. In 2018, the number of E. coli patients resistant to trimethoprim was the highest. Cephalexin and ciprofloxacin trends indicate the reduc- tion of the line during this retrospective period. There was a significant correlation between wards and some antibiotics like Cefepime, Cefotaxime, Ceftazidime, and Trimethoprim (P-Value <0.05).

Conclusion: Significant correlations were identified between specific hospital wards and resistance to antibiotics. These findings underscore the need for continuous surveillance and tailored antibiotic stewardship programs to combat the rising trend of antibiotic resistance.