Adenovirus-5 and adenovirus-37 seropositivity in obese patients

Nur Gamze  Bostan; Ozge  Altinok; Süleyman  Buyukasik; Halil  Alis; Yasar Ali  Oner

doi:10.18502/ijm.v16i5.16804

Nur Gamze Bostan Department of Medical Microbiology, Faculty of Medicine, Istanbul Aydin University, Istanbul, Türkiye
Ozge Altinok Department of Medical Microbiology, Faculty of Medicine, Istanbul Aydin University, Istanbul, Türkiye
Süleyman Buyukasik Department of General Surgery, Faculty of Medicine, Istanbul Aydin University, Istanbul, Türkiye
Halil Alis Department of General Surgery, Faculty of Medicine, Istanbul Aydin University, Istanbul, Türkiye
Yasar Ali Oner Department of Medical Microbiology, Faculty of Medicine, Istanbul Aydin University, Istanbul, Türkiye

DOI: https://doi.org/10.18502/ijm.v16i5.16804

Keywords: Obesity; Human adenovirus; Serotype; Adipocytes; Infections

Abstract

Background and Objectives: Obesity is a major health issue linked to conditions like diabetes, hypertension, and hy- perlipidemia. Infectobesity suggests that certain microorganisms may contribute to obesity. Human adenovirus serotypes, particularly Human adenovirus type-36 (HAdV-36), Human adenovirus type-5 (HAdV-5), and Human adenovirus type-37 (HAdV-37), are thought to influence body fat regulation. This study investigates the relationship between Immunoglobulin G (IgG) positivity for HAdV-5 and HAdV-37 and obesity, aiming to provide data on the infectious etiology of obesity.

Materials and Methods: Blood samples separated into serums from obese (BMI ≥30) and non-obese (BMI 18.5-25) indi- viduals were tested for HAdV-5 and HAdV-37 seropositivity using ELISA kits and seropositivity rates between the groups were compared.

Results: HAdV-37 antibody positivity was significantly higher in obese patients (39/48) compared to the control group (24/42) (p=0.011). For HAdV-5, antibody positivity was similar in both groups (26 individuals each) with no significant difference (p=0.461). No significant gender-related differences were found for either serotype.

Conclusion: The study suggests HAdV-37 may be associated with obesity, while no such relationship was found for HAdV-

There was no gender association for either serotype. These results align with existing literature on HAdV-37, but further research is needed to confirm the link between adenoviruses and obesity and explore potential treatment options.