Bacterial etiology, antimicrobial resistance and factors associated with community acquired pneumonia among adult hospitalized patients in Southwest Ethiopia

Abdulhakim Mussema; Getenet Beyene; Esayas  Kebede Gudina; Dagninet Alelign; Tofik Mohammed; Solomon Gebre Bawore; Abdurezak Mohammed Seid; Wondwossen Tadesse; Mulatu Gashaw

doi:10.18502/ijm.v15i4.13503

Abdulhakim Mussema Department of Medical Microbiology, School of Medical Laboratory Science, Wachemo University, Hosanna, Ethiopia
Getenet Beyene Department of Medical Microbiology, School of Medical Laboratory Science, Jimma University, Jimma, Ethiopia
Esayas Kebede Gudina Department of Internal Medicine, School of Medicine, Jimma University, Jimma, Ethiopia
Dagninet Alelign Department of Medical Microbiology, School of Medical Laboratory Science, Arba Minch University, Arba Minch, Ethiopia
Tofik Mohammed Department of Internal Medicine, School of Medicine, Arba Minch University, Arba Minch, Ethiopia
Solomon Gebre Bawore Department of Medical Microbiology, School of Medical Laboratory Science, Wachemo University, Hosanna, Ethiopia
Abdurezak Mohammed Seid Department of Medical Microbiology, School of Medical Laboratory Science, Wachemo University, Hosanna, Ethiopia
Wondwossen Tadesse Department of Medical Microbiology, School of Medical Laboratory Science, Wachemo University, Hosanna, Ethiopia
Mulatu Gashaw Department of Medical Microbiology, School of Medical Laboratory Science, Jimma University, Jimma, Ethiopia

DOI: https://doi.org/10.18502/ijm.v15i4.13503

Keywords: Pneumonia; Bacterial; Etiology; Antimicrobial drug resistance; Hospitalized; Ethiopia

Abstract

Background and Objectives: Antibiotic resistance is a significant problem that restricts the options for treating bacterial pneumonia. This research aimed to determine the bacterial causes of pneumonia and antibiotic resistance among hospitalized patients in southwest Ethiopia.

Materials and Methods: We collected and analyzed 150 sputum samples from individuals with community-acquired pneu- monia from April 1st to October 30th, 2019. Standard bacteriological procedures were used to identify the bacteria. Kirby Bauer's disk diffusion method was used to assess the bacteria's susceptibility patterns. Production of carbapenemase and extended-spectrum-lactamase were confirmed phenotypically. Odds ratios and the chi-square test were computed.

Results: On the whole, bacterial pathogens were verified in 50% of the sputum samples. The predominant bacterial isolates were Klebsiella species, followed by Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. About 77.5% of isolates were multidrug resistant. Moreover, 40.5% and 10.8% of the isolates were ESBL and carbapene- mase producers, respectively. Aging, tobacco smoking, previous history of pneumonia, heart disease, and chronic respiratory disease had association with sputum culture-positivity.

Conclusion: As a result, it is important to regularly monitor the bacterial etiologies and their patterns of resistance. Addition- ally, sociodemographic and clinical characteristics should all be taken into account while managing patients with pneumonia empirically in this context.