Histopathological characteristics and HPV status in cervical biopsy specimens diagnosed as flat condyloma

Fatemeh Nategh; Mitra Mohit; Minoo Saatian; Zohreh Farahmand; Hoorieh Soleimanjahi

doi:10.18502/ijm.v15i3.12909

Fatemeh Nategh Department of Public Medicine, School of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
Mitra Mohit Department of Obstetrics and Gynecology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
Minoo Saatian Department of Pathology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
Zohreh Farahmand Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Hoorieh Soleimanjahi Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

DOI: https://doi.org/10.18502/ijm.v15i3.12909

Keywords: Human papillomavirus viruses; Human papillomavirus; Human papillomavirus; Sexually transmitted diseases; Warts

Abstract

Background and Objectives: HPV infections cause a wide spectrum of pathological changes in lower anogenital epithe- lium. The aim of this study was to investigate the HPV DNA status and histological findings in cervical biopsy specimens diagnosed as flat condyloma.

Materials and Methods: This study included 20 cervical biopsy specimens diagnosed as flat condyloma. The histopatholog- ical criteria and presence of HPV DNA were evaluated. HPV genotyping was determined in HPV-positive specimens using BioEdit software and the results were analyzed in SPSS software.

Results: HPV DNA was not found in 30% of specimens and relative frequency of HPV genotypes was: 15% HPV6, 15% HPV11, 5% HPV16, 5% HPV18, 5% HPV53, 5% HPV68, 5% HPV84, 10% HPV45. Relative frequency of histopathologi- cal criteria was as below: 100% of specimens had koilocytosis, 100% acanthosis, 15% nuclear immaturity, 100% atypia, 15% mitotic activity, 50% dyskeratosis, 35% parakeratosis and 10% hyperkeratosis.

Conclusion: There were significant differences between HPV positivity and two pathologic criteria; multinucleation and hyperkeratosis (P Value: 0.02). Nuclear immaturity was significantly more prevalent in high risk HPV-positive specimens (P Value: 0.03).