Clinical Characteristics, Diagnostic Challenges, and Therapeutic Outcomes in Non-eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases in Comparison with Eosinophilic Esophagitis

Authors

  • Azizollah Yousefi Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  • Saeed Sepehry Vafa Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Mina Mirzad Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Fatemeh Elham Mahjoub Department of Pediatrics, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Behnam Shahsavand Department of Pediatrics, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Ebrahim Babaee Department of Community and Family Medicine, Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Fereshteh Karbasian Department of Pediatric Gastroenterology and Hepatology, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Mohammad Nabavi Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Mohammad Hasan Bemanian Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Sima Shokri Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Saba Arshi Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Morteza Fallahpour Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.18502/ijaai.v25is11.22484

Keywords:

Delayed diagnosis treatment outcome; Eosinophilic colitis; Eosinophilic esophagitis; Eosinophilic gastroenteritis; Eosinophilic gastrointestinal disease; Food allergy

Abstract

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments.

This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types.

Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more common in EoE (72% vs 47.5%). The overall clinical response rate was 88.29%, with most patients using food avoidance (90.99%) and proton pump inhibitors (94.59%). Clinical relapses occurred in 38.88% over the mean follow-up of 4.62 years and were unaffected by therapy type. Failure to thrive was seen in 26.7%, with no significant intergroup difference.

This study highlights a prolonged diagnostic delay in EoE vs non-EoE EGIDs. Both groups showed similar, favorable response rates, underscoring a need for greater awareness. Prospective studies with standardized measures are required to optimize management.

Published

2026-09-02

Issue

Volume (25) issue (s11)

Section

Articles