Correlation between Component-resolved Diagnostics (CRD) and Clinical Symptoms in Allergic Children: A One-year Study at the Children's Medical Center (April 2023–March 2024)

Maedeh  Khoshkam; Mahshid  Movahedi; Mohammad  Gharagozlou; Monir Farokhzadeh  Soltani; Masoud  Movahedi

doi:10.18502/ijaai.v25i1.20432

Maedeh Khoshkam Division of Allergy and Clinical Immunology, Department of Pediatrics, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mahshid Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Gharagozlou Division of Allergy and Clinical Immunology, Department of Pediatrics, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Monir Farokhzadeh Soltani Division of Allergy and Clinical Immunology, Department of Pediatrics, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Masoud Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/ijaai.v25i1.20432

Keywords: Allergy; Clinical symptoms; Component resolved diagnosis

Abstract

Component- Resolved Diagnosis (CRD) is an effective tool in allergy diagnosis, that detects specific IgE to allergenic molecules. The ALEX (Allergy Explorer) test, commercially available since 2019, measures specific IgE to allergenic extracts and components associated with inhalant, food, animal, latex, and insect allergens. CRD results should be interpreted based on the patient's clinical history.

Since Children's Medical Center Hospital is one of the largest referral centers for allergic patients, we evaluated the results of the ALEX2 test in patients referred to this center and compared them with the patients’ clinical symptoms.

Clinical symptoms were concordant with positive CRD (ALEX2) test in 76.7% of cases. The overall agreement between positive allergen components and clinical symptoms was 58%.

These findings indicate that the ALEX2 test can improve diagnostic accuracy in allergic patients; however, positive test results should be interpreted in the context of the patient’s clinical history.