Effect of Montelukast and Budesonide Aerosol Inhalation in the Treatment  of Allergic Rhinitis and asthma in Children and Its Effect on the Inflammatory Response of Children

Hui  Li; Tiecheng  Zhang; Ziwei  Chen; Shipei  Gao

doi:10.18502/ijaai.v24i3.18677

Hui Li Department of Otolaryngology, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Hebei, China
Tiecheng Zhang Department of Otolaryngology, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Hebei, China
Ziwei Chen Department of Otolaryngology, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Hebei, China
Shipei Gao Department of Stomatology, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Hebei, China

DOI: https://doi.org/10.18502/ijaai.v24i3.18677

Keywords: Allergic rhinitis; Asthma; Budesonide; Inflammatory response; Montelukast

Abstract

Studies have investigated montelukast and budesonide aerosol inhalation for treating allergic rhinitis (AR) and bronchial asthma (BA) in children. However, there are significant variations in dosage and duration of administration. This research evaluated the efficacy in children with AR and BA and analyzed montelukast's impact on the inflammatory response.

This retrospective cohort study involved 100 children with AR and BA who were admitted to “Baoding Hospital, Beijing Children's Hospital Affiliated with the Capital Medical University” from October 2022 to September 2023. They were divided into a budesonide group (budesonide n=50) and a combination group (montelukast and budesonide, n=50). Comparisons were made between the two groups in terms of clinical efficacy, severity scores of AR and BA before and after treatment, inflammatory indicators (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), pulmonary function indicators (forced expiratory volume in the first second (FEV₁), peak expiratory flow rate (PEF)), and adverse reactions.

After treatment, the severity scores of AR and BA in the combination group were 4.00±0.93 points and 2.64±0.56 points, which were lower than those in the budesonide group (5.14±0.66 points and 3.31±0.65 points, respectively). The total response rate of the combination group (96.00%) was higher than that of the budesonide group (80.00%). The levels of IL-6 and TNF-α in the combination group were lower than those in the budesonide group, and the levels of FEV₁ and PEF in the combination group were higher than those in the budesonide group.

Mometasone combined with budesonide shows good treatment effects in children with AR and BA.