Association of Toxoplasmosis with Serum TGF-β, IL-17, and IL-6 Levels in Individuals with Diabetes

  • Mansour Dabirzadeh Department of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  • Mohsen Ghoryani Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  • Javad Poursamimi Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  • Bahman Fouladi Department of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Keywords: Cytokines; Diabetes mellitus; Immune system; Inflammation; Toxoplasmosis

Abstract

Cytokines play an essential role in regulating the interaction of immune cells in diabetes and infections such as toxoplasmosis. The purpose of this study was to examine the serum levels of interleukin (IL)-6, IL-17, and transforming growth factor-beta (TGF-β) in patients with type 1 and type 2 diabetes mellitus with toxoplasmosis, and to explore their inter-relationship.

Forty patients with diabetes mellitus, including 20 with type 1 and 20 with type 2, as well as 20 healthy subjects, voluntarily participated in the study. Each subject provided 5 mL of peripheral blood for enzyme-linked immunosorbent assay.

Subjects with type 2 diabetes mellitus who also had toxoplasmosis showed a significant increase in TGF-β levels and a decrease in IL-6 levels. In contrast, patients with type 1 diabetes mellitus displayed a slight increase in IL-6 and IL-17 levels compared to both the patients with type 2 diabetes and the healthy control group.

Our findings show an increase in TGF-β and a decrease in IL-6, which may suggest a reduction in inflammation and beta cell destruction in individuals with type 2 diabetes and toxoplasmosis. The elevated serum levels of IL-6 and IL-17 in individuals with type 1 diabetes further support the exacerbation of inflammation.

 

Published
2024-12-29
Section
Articles