Molecular Pathways Underlying the Therapeutic Effect of Stem Cells During Asthmatic Changes

Bahar Saljoughi  Berenji; Fatemeh  Mirershadi

doi:10.18502/ijaai.v23i6.17372

Bahar Saljoughi Berenji Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
Fatemeh Mirershadi Department of Physiology, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran

DOI: https://doi.org/10.18502/ijaai.v23i6.17372

Keywords: Airway inflammation; Asthma; c-Kit cells; Mesenchymal stem cells; Therapeutics

Abstract

Allergic asthma is a chronic inflammatory disease characterized by airway remodeling, hyperresponsiveness, and exacerbated inflammation. While most patients respond well to current treatments, a small subset remains resistant necessitating new therapeutic strategies. Due to their immunomodulatory properties, stem cells have been proposed as a promising treatment option for asthma. Stem cells can reduce airway inflammation and restore immune balance, demonstrating positive outcomes, particularly in cases of steroid-resistant asthma. However, the mechanisms underlying lung tissue repair are not clearly defined. On the other hand, there are limitations in using these cells and for clinical use of mesenchymal stem cells, which must be produced in accordance with Good Manufacturing Practice. This review article discusses the mechanisms by which stem cells may aid in asthma treatment and addresses and explores the challenges associated with their use. By addressing these areas, we can better understand the potential and limitations of stem cell therapy in asthma and develop more effective strategies to harness their therapeutic benefits for patients with uncontrolled asthma.