Research Progress of Immune Mechanisms Related to Persistent HPV Infection in CIN after Cervical Conization

Jingyi  Yang; Fengxia  Xue

doi:10.18502/ijaai.v23i5.16755

Jingyi Yang Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China
Fengxia Xue Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China

DOI: https://doi.org/10.18502/ijaai.v23i5.16755

Keywords: Cervical intraepithelial neoplasia; Cervical conization; Immune mechanisms; Persistent human papillomavirus infection; Research progress

Abstract

Persistent human papillomavirus (HPV) infection is associated with the grading of cervical
intraepithelial neoplasia (CIN), high-risk HPV infection, multiple HPV infections, high HPV load,
HPV infection of surgical margin, and age in CIN after conization. The immune mechanism is
complex and is primarily related to vaginal microecology disorders, immune escape, immune
response impairment, and the release of regulatory cytokines. Currently, the treatment methods for
postoperative persistent HPV infection include surgical treatment, antiviral treatment, vaccination,
and other approaches.