The Efficacy of Budesonide-formoterol in Patients with Acute Attacks  of Mild-to-moderate Bronchial Asthma: An Observational Study

Yutong Li; Weitong Zeng; Qinyong Lu; Weimou Yin; Shiting Huang; Hanyi Wei; Longxiong Liao; Jiajiang Zhong; Xuejun Qin

doi:10.18502/ijaai.v23i4.16210

Yutong Li Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Weitong Zeng Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Qinyong Lu Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Weimou Yin Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Shiting Huang Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Hanyi Wei Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Longxiong Liao Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Jiajiang Zhong Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China
Xuejun Qin Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Guangxi, China

DOI: https://doi.org/10.18502/ijaai.v23i4.16210

Keywords: Acute exacerbation; Bronchial asthma; Budesonide; Combination therapy; Formoterol; Pulmonary ventilation function; Treatment efficacy

Abstract

To assess the impact of budesonide-formoterol on pulmonary ventilation function and prognosis in patients with mild-to-moderate acute exacerbations of bronchial asthma.

A retrospective analysis was conducted on clinical data from 232 patients with acute exacerbations of bronchial asthma. These patients were divided into 2 groups based on their treatment: a control group (n=104) receiving budesonide dry powder inhalation and an observation group (n=107) receiving budesonide-formoterol dry powder inhalation. Clinical efficacy and safety indicators were compared.

The results showed that the total treatment effectiveness rate in the observation group was significantly higher than that in the control group. Following treatment, the observation group exhibited significantly higher scores in the Asthma Quality of Life Questionnaire (AQLQ), as well as improved levels of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF), compared to the control group. Moreover, levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein were significantly lower in the observation group. The incidence of adverse reactions between groups was comparable.

Based on these findings, the application of budesonide-formoterol demonstrated significant effectiveness in patients with mild-to-moderate acute exacerbations of bronchial asthma. The combination therapy led to improved clinical outcomes, including enhanced pulmonary ventilation function and reduced inflammatory markers. Importantly, the safety profile of budesonide-formoterol was comparable to that of budesonide monotherapy. These results highlight the potential benefits of using budesonide-formoterol as an alternative treatment option for patients experiencing acute exacerbations of mild-to-moderate bronchial asthma.