A Case of Insidious Onset of Kimura Disease-associated Immunoglobulin A Nephropathy without Eosinophil Infiltration in the Renal Tissue

Linxin Liu; Haoxian Gou; Yongfa Liu; Shuai Hu; Xiaoli Yang; Bo Li

doi:10.18502/ijaai.v22i6.14649

Linxin Liu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Haoxian Gou Department of Hepatobiliary Pancreatic Surgery, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
Yongfa Liu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Shuai Hu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Xiaoli Yang Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Bo Li Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

DOI: https://doi.org/10.18502/ijaai.v22i6.14649

Keywords: Immunoglobulin A nephropathy; Infiltration of eosinophils; Kimura disease; Renal involvement

Abstract

Kimura disease (KD), also known as eosinophilic lymphogranuloma, is a rare chronic inflammatory or allergic disease. It can present with immune-related diseases such as nephrotic syndrome, asthma, and ankylosing spondylitis. In this study, we report a case of KD combined
with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed
by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration
was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.