Comparing Budesonide and Fluticasone Propionate in Children with Moderate to Severe Asthma: A Pilot Randomized Controlled Trial

Mansour Sadeghzadeh; Parisa Khoshnevisasl; Akefeh Ahmadiafshar; Nima Motamed; Azadeh Pourmarjani

doi:10.18502/ijaai.v22i6.14642

Mansour Sadeghzadeh Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran
Parisa Khoshnevisasl Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Akefeh Ahmadiafshar Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran
Nima Motamed Department of Community Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Azadeh Pourmarjani Department of Pediatrics, Ayatollah Moussavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

DOI: https://doi.org/10.18502/ijaai.v22i6.14642

Keywords: Asthma; Budesonide; Children; Clinical trial; Fluticasone propionate

Abstract

The aim of asthma treatment is to reduce airway inflammation by avoiding environmental triggers and using daily anti-inflammatory medications. This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical symptoms and control of asthma in children with moderate to severe asthma.

In this open-label study, children with moderate to severe asthma were randomly selected to receive either FP 250 mcg or Bud 400 mcg for 3 months. Asthma control test scores were measured in both groups monthly. The clinical symptoms, drug adherence, and rescue medication were also evaluated.

A total of 50 patients with ages between 4 and 7 years old were included in the study (25 cases received Bud and 25 cases received FP). Asthma control test scores, daily and nocturnal symptoms, and cough rates were significantly improved in both groups. The average asthma control scores for the fluticasone group were 21.68±3.32 in the second month and 24.84±2.67 in the third month, whereas the budesonide group had scores of 18.52±3.32 and 22.48±4.12 during the same periods. These variances were statistically significant. Additionally, the requirement for salbutamol use was notably reduced in the fluticasone group compared to the budesonide group throughout all three months.

The efficacy of fluticasone propionate in decreasing the need for rescue medication and enhancing asthma control test scores was markedly superior to that of budesonide.