Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation  and Imbalance

Reza Dabbaghipour; Elham Ahmadi; Mona Entezam; Omid Rahbar Farzam; Amir Baghbanzadeh; Ali Saber Sichani; Nazila Jalilzadeh; Mahdi Jafarlou; Behzad Baradaran

doi:10.18502/ijaai.v22i6.14641

Reza Dabbaghipour Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
Elham Ahmadi Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mona Entezam Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
Omid Rahbar Farzam Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Baghbanzadeh Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Ali Saber Sichani Department of Biology, Texas A&M University, College Station, Texas, USA
Nazila Jalilzadeh Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mahdi Jafarlou Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Behzad Baradaran Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

DOI: https://doi.org/10.18502/ijaai.v22i6.14641

Keywords: Long non-coding RNA; Regulatory T cells; T helper 17 cells

Abstract

Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.