The Study of Relationship between Serum Levels of Soluble fms-like Tyrosine Kinase-1 and Soluble Fibrinogen-like Protein 2 with Delayed  Graft Function after Kidney Transplantation

Hossein  Akbari; Zahra  Hooshyar; Saeede  Shabanitabar; Ali  Salmani; Hassan  Nikoueinejad; Behzad  Einollahi

doi:10.18502/ijaai.v18i4.1419

Hossein Akbari
Zahra Hooshyar
Saeede Shabanitabar
Ali Salmani
Hassan Nikoueinejad
Behzad Einollahi

DOI: https://doi.org/10.18502/ijaai.v18i4.1419

Keywords: Delayed graft function; Kidney transplantation; Soluble VEGF receptor-1; Soluble fibrinogen-like protein 2

Abstract

Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble fibrinogen-like protein 2 (sFGL-2) with DGF after transplantation.

This case-control study was done in 2 groups of 58 kidney transplant patients with and without DGF. The control group included the patients who didn’t show DGF symptoms. Then, serum levels of sFlt-1and sFGL-2 in all blood samples were measured by ELISA.

Serum sFlt-1 and sFGL-2 levels were significantly higher in the DGF group compared to those in the control group (p≤0.001). sFlt-1 and sFGL-2 serum levels significantly affect DGF (p<0.001) in such a way that they may be diagnostic factors of DGF.

This study showed a significant relationship between sFlt-1 as well as sFGL-2 and DGF. Therefore, plasma levels of sFlt-1 and sFGL-2 may be used as diagnostic tools to determine the risk of DGF.