Immune Profiling of SARS-CoV-2; What We Know and What We Don’t Know

Mahshid Zohouri; Atri Ghods; Mina Roshan Zamir; Fazel Shokri; Abbas Ghaderi

doi:10.18502/ijaai.v22i3.13050

Mahshid Zohouri Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Atri Ghods Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mina Roshan Zamir Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Fazel Shokri Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abbas Ghaderi Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/ijaai.v22i3.13050

Keywords: Adaptive immunity; Coronavirus disease 2019; Immunology; Innate immunity; Physiopathology; Severe acute respiratory syndrome coronavirus 2

Abstract

Coronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. There is still no cure because of the complicated pathogenesis, however, there are several studies on track investigating different aspects of the immune response to the virus. In this review, we will provide an overview of recent investigations that have analyzed immune cells in patients with COVID-19. We will then discuss the differences in immune profiles between healthy controls and various clinical presentations, including asymptomatic, mild, moderate, and severe cases.