COVID-19 in Chronic Granulomatosis Disease: A Case Report

Hossein Esmaeilzadeh; Seyed Sina Dehghani; Babak Shahhoseini; Soheila Alyasin; Sayyed Hesamedin Nabavizadeh; Aida Askari

doi:10.18502/ijaai.v21i4.10295

Hossein Esmaeilzadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Sina Dehghani Department of Pediatric, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Babak Shahhoseini Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Soheila Alyasin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Sayyed Hesamedin Nabavizadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Aida Askari Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/ijaai.v21i4.10295

Keywords: Chronic granulomatous disease; Coronavirus disease 2019

Abstract

A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses.