Efficacy of lacosamide in the treatment of non-convulsive seizure and non-convulsive status epilepticus in septic patients: a narrative review

Kiumarth Amini; Adeleh Sahebnasagh; Mojtaba Mojtahedzadeh

doi:10.18502/fem.v6i3.9401

Kiumarth Amini Student Research Committee, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Adeleh Sahebnasagh Clinical Research Center, Department of Internal Medicine, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Mojtaba Mojtahedzadeh Department of Clinical Pharmacy, Pharmaceutical Research Institute, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/fem.v6i3.9401

Keywords: Critically Ill, Intensive Care Unit, Lacosamide, Non-convulsive Seizures, Non-convulsive Status Epilepticus, Sepsis

Abstract

Non-convulsive seizures (NCS) and non-convulsive status epilepticus (NCSE) are of the acute complications of patients admitted to the intensive care unit (ICU), which lead to increased mortality and morbidity. In these cases, immediate treatment with antiepileptic drugs (AEDs) is important to prevent further damage to the brain. AEDs are the first line of treatment, however, most of these medications have many side effects. In the recent years, significant advances have been made in this area and lacosamide is one of the therapeutic options. The intravenous formulation of this drug is most popular due to the lack of drug-drug interaction and properly designed studies which have been conducted in this field. In this review, the latest findings on the effect of lacosamide on acute non-convulsive and generalized-convulsive seizures (G-CS) are evaluated in critically ill patients admitted to the ICU.