Antifungal effect of the effect of Securigera securidaca L. vaginal gel on Candida species

Atefeh   Raesi Vanani; Masoud  Mahdavinia; Heibatullah   Kalantari; Saeed  Khoshnood; Maryam   Shirani

doi:10.18502/cmm.5.3.1744

Atefeh Raesi Vanani
Masoud Mahdavinia
Heibatullah Kalantari
Saeed Khoshnood
Maryam Shirani

DOI: https://doi.org/10.18502/cmm.5.3.1744

Keywords: Antifungal effect, Candida albicans, Candidiasis, Vaginal gel

Abstract

Background and Purpose: Candida species are opportunistic fungi, capable of causing acute and chronic infections in the gastrointestinal tract, vagina, and oral mucosa, among which Candida albicans is the most important species. The Securigera securidaca L. is used as an antiseptic to treat some diseases in traditional Iranian medicine. The aim of this study was to evaluate the antimicrobial activity of S. securidaca extracts and vaginal gel against different Candida species.

Materials and Methods: Antifungal effects of different extracts and vaginal gel of S. securidaca were investigated against Candida species. By using well diffusion test, different concentrations of the collected S. securidaca extracts and vaginal gel were examined to test their antifungal activity against C. albicans, C. parapsilosis, and C. krusei.

Results: The ethanol extract and vaginal gel with the ethanol extract of S. securidaca showed the most anti-fungal activity against all three strains.

Conclusion: The S. securidaca extract had a significant inhibitory effect on the different species of Candida; however, the highest inhibitory effect was found against C. albicans. In order to treat candidiasis, more research is required to check the efficacy of this plant in this domain.