Comparison of seasonal pattern in patients with warfarin overdose

Haleh  Bodagh; Ahmad  Separham; Razieh   Parizad; Leila  Vahedi; Peyman  Ghodrati; Mohamad  Bager Bodagh; Bita  Amiri

doi:10.18502/cbj.v1i1.7548

Haleh Bodagh Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Ahmad Separham Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Razieh Parizad Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Leila Vahedi Liver and Gastrointestinal Diseases Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
Peyman Ghodrati Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohamad Bager Bodagh Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Bita Amiri Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

DOI: https://doi.org/10.18502/cbj.v1i1.7548

Keywords: Comparison; Warfarin; Drug overdose; Season Age

Abstract

Objectives: The most common anticoagulant drug in the world is warfarin. Overdoses of warfarin may follow seasonal patterns, but the information is scarce. This study investigated possible seasonal variations in warfarin overdose among various age groups living in cold climates.

Results: Seasonal patterns were observed in warfarin overdoses. Warfarin overdoses were more common among the patients under 65 years old during winter (P-value = 0.03), whereas almost identical findings were found among the patients 65 and older, although numerically more cases were seen during the summer season (P-value = 0.8).

Conclusions: The results of the current study showed that warfarin overdoses in the patients younger than 65 years showed a seasonal pattern peaking in the winter months. However, these findings did not have any relation with older patients. To confirm the results of the present study, larger prospective multicenter studies in a variety of climate settings are needed.