Evaluation of ventricular tachyarrhythmias in patients with myocardial infarction after streptokinase therapy

Mohsen  Abbasnezhad; Golnesa   Shahnazarli; Mohammadreza  Taban Sadeghi; Razieh   Parizad; Naser   Khezerlouy Aghdam; Babak Nasiri; Bijan  Zamani

doi:10.18502/cbj.v1i1.7510

Mohsen Abbasnezhad Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Golnesa Shahnazarli Department of Midwifery and Reproductive Health, School of Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammadreza Taban Sadeghi Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Razieh Parizad Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Naser Khezerlouy Aghdam Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Babak Nasiri Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Bijan Zamani School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

DOI: https://doi.org/10.18502/cbj.v1i1.7510

Keywords: Cardiac arrhythmia; Electrocardiography; Myocardial infarction; Streptokinase therapy

Abstract

Objectives: The occurrence of arrhythmias after myocardial infarction is associated with an increased risk of mortality. The purpose of this study was to investigate tachyarrhythmias after streptokinase therapy in myocardial infarction patients.

Methods: This study was a case-control study. Among 262 patients with myocardial infarction who received streptokinase, 168 patients with ventricular tachyarrhythmia, ventricular fibrillation, or both (case group), and 94 patients without arrhythmia (control group) were selected. Their clinical information were collected by questionnaire. Data were analyzed using SPSS 20 software through chi-square test and Wilcoxon rank-sum.

Results: There was no relationship between demographic variables or electrocardiogram changes and the type of arrhythmia in 168 participants in the group 1 (p > 0.05). However, there was a significant relationship between age (p = 0.04), sex (p = 0.049), diabetes (p = 0.039), hypertension (p = 0.037), history of beta-blocker use (p = 0.028), history of aspirin use (p = 0.023), number of the leads involved (p = 0.023) and occurrence of arrhythmia among the participants in the group 2.

Conclusions: According to the findings of this study, patients with myocardial infarction who need to receive thrombolysis and who have any of the following conditions should be monitored by the health care staff to prevent development of ventricular tachyarrhythmias: old age, male gender, history of diabetes mellitus, hypertension or more lead involvement in their electrocardiogram.