Livedo reticularis following drug interaction of sertraline and amantadine in a patient with obsessive-compulsive disorder and depression: A brief report

  • Fatemeh Mohamadian Rasnani Assistant professor of Neurology.Department of Psychiatry, School of Medicine Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Somayeh Panahi Department of Psychology and Counseling, Ashkezar Branch, Islamic Azad University, Yazd, Iran.
  • Fatemeh Zare Pharmaceutical Sciences Research Center, School of Pharmacy, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Reza Bidaki Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Mohadeseh Asadi Department of Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Keywords: Livedo reticularis; Amantadine; Obsessive-compulsive disorder; Sertraline

Abstract

Livedo reticularis (LR) is a cutaneous vascular pattern that presents with reticular patch morphology. LR is a manifestation of a wide range of diseases, from idiopathic to systemic. We reported the clinical image of a patient with obsessive-compulsive disorder (OCD) and LR associated with amantadine use. On examination, mild postural tremor was left-handed and had a kinetic tremor. Rest tremor and re-emerge tremor were detected in addition to mild rigidity and bradykinesia in the patient; we proposed probable drug-induced Parkinsonism.

 We should notice skin lesions after amantadine use and consider LR after the prescription of it. Also, co-administration of SSRIs and amantadine may increasethe probability of LR.

Published
2022-02-12
Section
Articles