Livedo reticularis following drug interaction of sertraline and amantadine in a patient with obsessive-compulsive disorder and depression: A brief report

Fatemeh  Mohamadian Rasnani; Somayeh Panahi; Fatemeh Zare; Reza Bidaki; Mohadeseh Asadi

doi:10.18502/aptj.v1i2.8672

Fatemeh Mohamadian Rasnani Assistant professor of Neurology.Department of Psychiatry, School of Medicine Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
Somayeh Panahi Department of Psychology and Counseling, Ashkezar Branch, Islamic Azad University, Yazd, Iran.
Fatemeh Zare Pharmaceutical Sciences Research Center, School of Pharmacy, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Reza Bidaki Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohadeseh Asadi Department of Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: https://doi.org/10.18502/aptj.v1i2.8672

Keywords: Livedo reticularis; Amantadine; Obsessive-compulsive disorder; Sertraline

Abstract

Livedo reticularis (LR) is a cutaneous vascular pattern that presents with reticular patch morphology. LR is a manifestation of a wide range of diseases, from idiopathic to systemic. We reported the clinical image of a patient with obsessive-compulsive disorder (OCD) and LR associated with amantadine use. On examination, mild postural tremor was left-handed and had a kinetic tremor. Rest tremor and re-emerge tremor were detected in addition to mild rigidity and bradykinesia in the patient; we proposed probable drug-induced Parkinsonism.

We should notice skin lesions after amantadine use and consider LR after the prescription of it. Also, co-administration of SSRIs and amantadine may increasethe probability of LR.