Zika Virus Infection, Basic and Clinical Aspects: A Review Article

Farshid NOORBAKHSH; Kamal   ABDOLMOHAMMADI; Yousef  FATAHI; Hossein   DALILI; Mehrnaz  RASOOLINEJAD; Farshid   REZAEI; Mostafa   SALEHI-VAZIRI; Nazanin  Zahra SHAFIEI-JANDAGHI; Ehsan   Shamsi GOOSHKI; Morteza  ZAIM; Mohammad Hossein NICKNAM

doi:10.18502/ijph.v48i1.779

Farshid NOORBAKHSH
Kamal ABDOLMOHAMMADI
Yousef FATAHI
Hossein DALILI
Mehrnaz RASOOLINEJAD
Farshid REZAEI
Mostafa SALEHI-VAZIRI
Nazanin Zahra SHAFIEI-JANDAGHI
Ehsan Shamsi GOOSHKI
Morteza ZAIM
Mohammad Hossein NICKNAM

DOI: https://doi.org/10.18502/ijph.v48i1.779

Abstract

Background: Zika virus infection has recently attracted the attention of medical community. While clinical manifestations of the infection in adult cases are not severe and disease is not associated with high mortality rates, Zika virus infection can have an impact on fetal development and lead to severe neurodevelopmental abnormalities.

Methods: To gain insight into different aspects of Zika virus infection, a comprehensive literature review was performed. With regard to epidemiology and geographical distribution of Zika virus infection, relevant information was extracted from CDC and WHO websites.

Results: In this review, we discuss different basic and clinical aspects of Zika virus infection including virology, epidemiology and pathogenesis of disease. Laboratory methods required for the diagnosis of disease together with ethical issues associated with Zika virus infection will also be discussed in detail.

Conclusion: Herein, we have tried to provide a multi-faceted view of Zika virus infection, with greater emphasis on disease status in Eastern Mediterranean Region.