A Review on Plant-Derived Immunomodulatory Agents: Hopes as an Alternative Medicine in the Management of Immune-Related Disorders

K. Deepa Deva; B. Vanitha Bose; Duraiswamy  Basavan

doi:10.18502/tim.v8i2.13085

K. Deepa Deva JSS School of Life Science, JSS Academy of Higher Education and Research, Longwood Campus, Mysuru Road, Ooty, India
B. Vanitha Bose Department of Biochemistry, JSS School of Life Science, JSS Academy of Higher Education and Research, Longwood Campus, Mysuru Road, Ooty, India
Duraiswamy Basavan Department of Pharmacognosy and Phytopharmacy, JSS College of pharmacy, JSS Academy of Higher Education and Research, Rockland, Ooty, India

DOI: https://doi.org/10.18502/tim.v8i2.13085

Keywords: Immune system; Immunomodulators; T cells; Cytokines; Tumor necrosis factor; Interferons; Humoral and cellular immunity

Abstract

In humans, the immune system serves as a protective barrier against infection; however, when the immune system is out of balance, it can harm the host. Immunomodulators are chemicals or medications that have been employed in the clinic to treat an unbalanced immune response. The majority of immunological medicines in clinical use are cytotoxic. They harm the patient's quality of life by causing various side effects and being associated with higher production costs, longer lead times, and a high failure rate. Furthermore, obtaining single-compound chemicals with low toxicity, high efficacy, and selectivity for specified disorders is difficult for researchers. As a result, techniques based on alternative medicine are gaining attraction in drug development, focusing on innovative natural compounds utilized to treat various disorders. Many plant molecules founded to have biologically beneficial properties. This review aimed to look at the immunomodulatory activity of plant-derived chemicals from widely-used plants.