Investigating the Seroprevalence of HBV and HCV infection in Potential Donors: Study from Iranian Tissue Bank and Research Center (2014-2021)

Authors

  • Omid Salahi Ardekani Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Alireza Etrati Kooshali Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Saba Seyedi Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Ali Vasheghani Farahani Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Nazanin Mohammadlo Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Negar Asghari Hosori Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  • Sheida Sarrafzadeh Department of Epidemiology and Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran
  • Sedigheh Poursaleh Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Maryam Karami Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mahsa Salasi Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Ahmadreza Sadeghi Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.18502/ipj.v1i1.22943

Keywords:

HBV; HCV; Prevalence; Transplantation; Brain Death

Abstract

Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major contributors to liver disease and hepatocellular carcinoma (HCC), affecting millions worldwide. Transmission routes and clinical outcomes vary between the two viruses, with both posing significant challenges in transplantation. Understanding the seroprevalence of HBV and HCV is crucial for effective pre-transplant screening and post-transplant management to prevent disease transmission and recurrence. The present study aimed to investigate the prevalence of HBV and HCV in potential donors referred to the Iranian Tissue Bank and Research Center (ITBRC).

Methods: The study population was potential donors referred to ITBRC between 2014 and 2021, including two groups: brain death donors and forensic donors referred from the Iranian Legal Medicine Organization. For HBV, HBsAg and HBsAb; and for HCV, HCV-Ab were detected by ELISA.

Results: A total of 3862 individuals were studied (32.4% female and 67.6% male), including 1349 (34.9%) brain death and 2513 (65.1%) circulatory death donors. Analysis showed 1.19 times higher rates of HCV infection in women than in men, but this was not statistically significant. Logistic regression showed no significant effects of donor type on HCV infection rates. For HBV, brain death subjects had over three times higher odds of HBsAg-positive tests compared to circulatory death (OR = 3.06, p-value < 0.05). Additionally, female cases had lower odds of an HBsAg- positive test compared to males (OR = 0.56). The odds of a positive HBsAg test in brain death cases were 2.7 times higher than in circulatory death, with 3.49% of cases being positive for HBsAg and HBsAb test results.

Conclusion: In conclusion, this retrospective study demonstrated a higher prevalence of HBV-positive tests in brain death donors compared to circulatory death donors, with female donors showing lower odds of HBsAg-positive tests compared to males.

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Published

2026-10-12

Issue

Volume (1) issue (1)

Section

Articles