Spatio-Temporal Analysis of the Hepatitis B Prevalence in Irani-an Blood Donors from 2000 to 2016 at National and Provincial Level

Negar  Rezaei; Mahtab  Maghsodlu; Ali  Sheidaei; Sedigheh  Amini Kafiabad; Kimiya  Gohari; Maryam  Zadsar; Farnaz  Delavari; Zohreh  Sharifi; Moein  Yoosefi; Farshad  Farzadfar; Mohsen  Asadi-Lari

doi:10.18502/ijph.v50i9.7058

Negar Rezaei Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Mahtab Maghsodlu Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Ali Sheidaei Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Sedigheh Amini Kafiabad Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Kimiya Gohari Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Maryam Zadsar Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Farnaz Delavari Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Zohreh Sharifi Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Moein Yoosefi Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Farshad Farzadfar Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Mohsen Asadi-Lari Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/ijph.v50i9.7058

Keywords: Hepatitis B; Prevalence; Blood donors

Abstract

Background: High risk blood transfusions can cause a lot of financial and psychological burden to the community. The prevalence of Hepatitis B is useful for evaluating the blood products' safety and donor selection methods. We aimed to predict the prevalence of hepatitis B in Iranian blood donors from 2000-2016.

Methods: Positive cases of hepatitis B from 2006 to 2014 were collected from Iranian Blood Transfusion Organization. This database was classified according to the age, provinces, and type of donation. Data was not existed in all subnational levels and all years, therefore, for predicting the hepatitis B prevalence, two separate, Spatio-temporal and mixed model (GLMM) were developed.

Results: At the national level, the hepatitis B prevalence declined from 0.69 (0.51 to 0.90) in 2000 to 0.27 (0.21 to 0.33) in 2016. In first-time, regular, and repeated donors, this prevalence declined from 2.31 (1.74 to 2.31), 0.26 (0.19 to 0.34), and 0.51 (0.38 to 0.68) in 2000 to 0.87 (0.69 to 1.09), 0.09 (0.07 to 0.12), and 0.19 (0.14 to 0.24) in 2016. At the provincial level, the highest and lowest prevalence in 2016 was observed in North Khorasan and Gilan. With increasing age, the average prevalence of hepatitis B, increased.

Conclusion: Prevalence of hepatitis B in Iranian blood donors has been reduced significantly over 17 years, but still new cases of hepatitis B are reported. By precise monitoring the donor selection process and implementing more sensitive laboratory screening, we can reduce the risk of new infectious agents.