Evaluation of total and differential white blood cell counts in workers exposed to lead

F  Kargar-Shouroki; HR Mehri; F Sepahi-Zoeram

doi:10.18502/tkj.v13i3.8198

F Kargar-Shouroki Occupational Health Research Center, Department of Occupational Health Engineering, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
HR Mehri Department of Occupational Health Engineering, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
F Sepahi-Zoeram Department of Occupational Health Engineering, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

DOI: https://doi.org/10.18502/tkj.v13i3.8198

Keywords: lead, battery workers, differential white blood cell

Abstract

Introduction: Lead is a toxic heavy metal that has adverse health effects on blood parameters. About 80% of lead produced is used in batteries, especially vehicle batteries. Therefore, the present study aimed to assess the hematological changes, including total and differential white blood cell (WBC) counts in battery workers exposed to lead, and compare with the non-exposed group.

Materials and Methods: This cross-sectional study was carried out in a battery industry in Semnan city. The study population consisted of 78 battery workers and 78 healthy non-exposed office workers. A hematology cell counter was used to determine the total, and differential WBC counts. Blood lead level was measured in accordance with the NIOSH method 8003.

Results: Blood lead levels were about two times higher than the TLV recommended by the American Conference of Governmental Industrial Hygienists (ACGIH) for this compound (20 µg/dl). The level of WBC (8.07± 2.55 mm³ blood×10³ vs. 7.27 ± 1.58 mm³ blood×10³) was significantly higher, while the level of monocyte was significantly lower (6.96 ± 1.72 % vs. 7.67 ± 1.87 %) in the exposed group than in the non-exposed group. After adjustment for potential confounders such as age and work history, a significant association between exposure to lead and WBC and monocyte levels was reported.

Conclusion: The present study's findings indicated that exposure to lead was associated with total and differential white blood cells changes in the exposed group compared to the non-exposed group.