Recombinant probiotic-Based Vaccines; Attractive vehicles for immunization via mucosal routes

Seyyed Fatemeh Nabizadeh; Fatemeh Dehqan; Khalil  Khashei Varnamkhasti

doi:10.18502/ssu.v30i4.9891

Seyyed Fatemeh Nabizadeh Department of Medical Laboratory Sciences, School of Medicine, Islamic Azad University of Kazerun, Kazerun, Iran.
Fatemeh Dehqan Department of Medical Laboratory Sciences, School of Medicine, Islamic Azad University of Kazerun, Kazerun, Iran.
Khalil Khashei Varnamkhasti Department of Medical Laboratory Sciences, School of Medicine, Islamic Azad University of Kazerun, Kazerun, Iran.

DOI: https://doi.org/10.18502/ssu.v30i4.9891

Keywords: Vaccine, Recombinant probiotic, Mucosal immunization

Abstract

Introduction: The importance of genetically modified microorganisms, including probiotics, now widely have considered as attractive vehicles for mucosal delivery of therapeutic molecules. Previous studies have indicated that mucosal administration of these molecules can effectively trigger humoral along with cellular immune responses. Therefore, development of induction of mucosal immune responses, utilizing of recombinant probiotics-based vaccines, as live delivery vectors with no side effects in humans, may contribute to effectiveness of control strategies against infection agents.