Effect of Particulate Properties of Inhaled Dry Powder Formulation on Bioavailability, Dissolution Rate of Drug Particles and Rate of Drug Removal from the Body

Ali Akbar Alizadeh; Hamed Hamishehkar; Shadi Yaqoubi

doi:10.18502/ssu.v30i2.9276

Ali Akbar Alizadeh Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamed Hamishehkar Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shadi Yaqoubi Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: https://doi.org/10.18502/ssu.v30i2.9276

Keywords: Dry powder inhalation, Pulmonary drug delivery, Bioavailability, Drug formulation.

Abstract

Introduction: The use of pulmonary drug delivery as a non-invasive drug delivery system for the systemic treatment of diseases as well as the topical treatment of respiratory diseases is increasing. Among the various inhaled formulations, inhaled dry powders show advantages over the other forms of inhaled medicines due to high stability, bioavailability and ease of use. The effect of particle properties on the rate of drug delivery to the lungs in inhaled dry powders has been investigated in previous papers.

Conclusion: Since the physicochemical properties of particles of dry powder inhalation formulations such as particle size, surface and particle shape, as well as the electrical charge of the particles play a decisive role in drug pharmacokinetics, in the present review article we intended to discuss the effect of these parameters of inhaled dry powder formulations on bioavailability, dissolution rate of drug particles and the rate of drug clearance from the body.