An Overview of Immunogenetic in Celiac Disease

Abstract

Introduction: Celiac disease is an autoimmune disease caused by persistent intolerance to gluten, which is causedin people who are genetically predisposed.The disease presents with atrophy of the small intestinal mucosa and gastrointestinal and extra-gastrointestinal manifestations.Environmental factors like gluten and genetic factors such as HLA and non-HLA genes are involved in causing the disease.Mucosal atrophy results from an adaptive and innate immune response to gluten. T-helper, interleukin 15 and tumor necrosisfactor-alpha have a central role in this process. Recognize the risk of genetic factors and inflammatorymechanisms will help diagnose and treat the disease.